Indian-origin astronaut Shubhanshu “Shux” Shukla, pilot of the Axiom‑4 mission aboard the International Space Station, has made significant strides in bone health and radiation safety research. On the 10th flight day, he led the Bone on ISS experiment, analyzing how microgravity affects skeletal degradation and recovery. This research uses biological markers to create a digital twin - a personalized simulation of bone response - aiming to help foresee risks and guide targeted countermeasures for astronauts and patients with osteoporosis on Earth.

Additionally, Shukla participated in radiation monitoring using a Rad Nano Dosimeter, capturing real-time exposure data crucial for planning safer long-duration deep-space missions . These experiments, part of the Axiom‑4 mission’s 60-research portfolio, underline the growing India‑ISRO collaboration within global space science .

Together, the bone and radiation studies reflect a dual benefit - enhancing astronaut health protocols and contributing to terrestrial medical science, reinforcing Shukla’s pivotal role in bridging space exploration and Earth-bound wellness strategies.